Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet
Objectives: Elevated plasma glucagon is an early symptom of diabetes, occurring shellac starter set douglas in subjects with impaired glucose regulation.Here, we explored alpha-cell function in female mice fed a high-fat diet (HFD).Methods: Female mice expressing the Ca2+ indicator GCaMP3 specifically in alpha-cells were fed a high-fat or control (